Platform

Unlock nature's cellular gateways

Bonito has rebuilt encoded library technologies and live-cell selection technologies from the ground up, specifically for delivery ligand discovery. Our data provide an order of magnitude improvement in signal-to-noise and can be generated directly on membrane-bound targets, including for small-molecule ligand discovery. Together, these technologies offer unparalleled data generation for AI model development against a major constraint: precision drug delivery.

Three-part engine

From physical selections to programmable delivery.

Encoded libraries, functional selections, and AI work together to turn physical delivery experiments into programmable ligand discovery.

Encoded libraries
Physically test billions of compounds for delivery.

Bonito rebuilt encoded library technology specifically for delivery ligand discovery, turning giga-scale molecular diversity into selectable, functional cellular signal.

Functional selections
Go beyond binding to select for what really matters: delivery.

Bonito screens hundreds of billions of encoded ligands against complex cellular delivery phenotypes, capturing high-dimensional information related to receptor engagement and cellular delivery.

AI
Program delivery ligands for any cell or tissue type.

High-density enrichment data becomes training signal for models that can rank ligands, expose delivery rules, and generalize across cellular gateways.

Platform

Membrane bound targets

Select directly in the biological context where delivery happens.

Delivery ligands must do more than bind cleanly in isolation. Bonito's live-cell workflow is designed to preserve target presentation, cellular uptake behavior, and the functional signal needed to learn the rules that govern ligand-payload delivery.